phosphatidate phosphatase LPIN2; lipin-2 (LPIN2, KIAA0249)

Function

• roles in controlling metabolism of fatty acids at differents levels
• Mg+2-dependent phosphatidate phosphatase enzyme
• catalyzes conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine & phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane
• nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (putative)
• inhibited by N-ethylmaleimide (putative)

Cofactor: Mg+2 (putative)

Structure

• contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity
• contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif (putative)
• belongs to the lipin family

Compartment

• nucleus (putative)
• cytoplasm, cytosol (putative)
• endoplasmic reticulum membrane
• translocates to endoplasmic reticulum membrane with increasing levels of oleate (putative)

Expression

• expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, & colon

Pathology

• defects in LPIN2 are the cause of Majeed syndrome

More general terms

• lipin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9663
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9663
• OMIM: https://mirror.omim.org/entry/605519
• OMIM: https://mirror.omim.org/entry/609628
• UniProt: http://www.uniprot.org/uniprot/Q92539.html