atonal protein homolog 1 (helix-loop-helix protein hATH-1, ATOH1, ATH1)

Function

• activates E box-dependent transcription in association with TCF3/E47
• activity antagonized by negative regulator of neurogenesis HES
• role in differentiation of subsets of neural cells by activating E box-dependent transcription
• efficient DNA binding requires dimerization with another bHLH protein

Structure

• contains 1 basic helix-loop-helix (bHLH)

Compartment

nucleus

More general terms

• DNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/601461
• UniProt: http://www.uniprot.org/uniprot/Q92858.html