thyroid transcription factor 1; NK-2 (drosophila) homolog A; thyroid nuclear factor (TTF1, NKX2A, NKX2-1)

Function

• may play role in surfactant homeostasis

Expression

• thyroid
• pulmonary epithelial cells

Embryogenesis:

• thyroid
• diencephalon
• respiratory epithelium

Pathology

• expressed in:
  • thyroid tumors (all histologic types)
  • lung carcinomas
    • adenocarcinomas ~75%
    • non-small cell carcinomas ~63%
    • neuroendocrine/small cell carcinomas >90%
    • squamous carcinomas ~10%

More general terms

• DNA-binding protein
• homeobox protein

Database

• OMIM: https://mirror.omim.org/entry/600635
• UniProt: http://www.uniprot.org/uniprot/P43699.html