insulin-like growth factor-binding protein-like 1 (insulin-like growth factor-binding-related protein 4, IGFBP-related protein 10, IGFBP-rP4, IGFBPL1, IGFBPRP4)

Function

• IGF-binding proteins prolong the half-life of IGFs & either inhibit or stimulate the growth promoting effects of the IGFs in cell culture; they alter interaction of IGFs with their cell surface receptors
• putative tumor suppressor protein

Structure

• contains 1 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 IGFBP N-terminal domain
• contains 1 Kazal-like domain

Compartment

secreted

Expression

• expressed brain & testis > prostate, bladder & lung
• down-regulated in multiple tumors

More general terms

• insulin-like growth factor [IGF]-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8WX77.html