trypsin-3; brain trypsinogen; mesotrypsinogen; serine protease 3; serine protease 4; trypsin III; trypsin IV (PRSS3, PRSS4, TRY3, TRY4)

Function

• digestive protease specialized for degradation of trypsin inhibitors
• in the ileum, may be involved in defensin processing, including DEFA5
• preferential cleavage: Arg-|-Xaa, Lys-|-Xaa

Cofactor: binds 1 Ca+2 per subunit

Structure

• belongs to the peptidase S1 family
• contains 1 peptidase S1 domain

Compartment

secreted

Alternative splicing

named isoforms=4; A, B, C, D

Expression

• expressed in pancreas & brain
• also expressed in paneth cells, at the base of small intestinal crypts

More general terms

• trypsin
• Ca+2 binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5646
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5646
• OMIM: https://mirror.omim.org/entry/613578
• UniProt: http://www.uniprot.org/uniprot/P35030.html