defensin-5; defensin, alpha 5 (DEFA5, DEF5)

Function

• antimicrobial activity against Gram-negative & Gram-positive bacteria
• defensins are thought to kill microbes by permeabilizing their plasma membrane

Structure

• homodimer
• belongs to the alpha-defensin family

Compartment

secreted

Expression

• found in Paneth cells of intestinal tract

More general terms

• defensin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1670
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1670
• OMIM: https://mirror.omim.org/entry/600472
• UniProt: http://www.uniprot.org/uniprot/Q01523.html