A disintegrin & metalloproteinase with thrombospondin type 1 motif 18; ADAMTS-18; ADAM-TS 18; ADAM-TS18 (ADAMTS18, ADAMTS21)

Function

• precursor is cleaved by a furin endopeptidase

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
• dissociation of Cys from Zn+2 upon the activation- peptide release activates the enzyme
• contains 1 disintegrin domain
• contains 1 peptidase M12B domain
• contains 1 PLAC domain
• contains 5 TSP type-1 domains

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in fetal lung, liver, & kidney & in adult brain, prostate, submaxillary gland, & endothelium

More general terms

• ADAMTS protease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=170692
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:170692
• OMIM: https://mirror.omim.org/entry/607512
• UniProt: http://www.uniprot.org/uniprot/Q8TE60.html