A disintegrin & metalloproteinase with thrombospondin type 1 motif 16; ADAMTS-16; ADAM-TS 16; ADAM-TS16 (ADAMTS16, KIAA2029)
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Function
- precursor is cleaved by a furin endopeptidase
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure
- spacer domain & TSP type-1 domains are important for a tight interaction with the extracellular matrix
- the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
- dissociation of Cys from Zn+2 upon activation- peptide release activates the enzyme
- contains 1 disintegrin domain
- contains 1 peptidase M12B domain
- contains 1 PLAC domain
- contains 6 TSP type-1 domains
Compartment
Alternative splicing
named isoforms=2