A disintegrin & metalloproteinase with thrombospondin type 1 motif 15; ADAMTS-15; ADAM-TS 15; ADAM-TS15 (ADAMTS15)

Function

• precursor is cleaved by a furin endopeptidase

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
• the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
• dissociation of Cys from Zn+2 upon activation- peptide release activates the enzyme
• contains 1 disintegrin domain
• contains 1 peptidase M12B domain
• contains 3 TSP type-1 domains

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

• expressed in fetal liver & kidney
• not expressed in any adult tissues examined

More general terms

• ADAMTS protease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=170689
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:170689
• OMIM: https://mirror.omim.org/entry/607509
• UniProt: http://www.uniprot.org/uniprot/Q8TE58.html