A disintegrin & metalloproteinase with thrombospondin type 1 motif 10; ADAMTS-10; ADAM-TS 10; ADAM-TS10; (ADAMTS10)

Function

• interaction with the extracellular matrix

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
• contains 1 disintegrin domain
• contains 1 peptidase M12B domain
• contains 1 PLAC domain
• contains 5 TSP type-1 domains

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

widely expressed in adult tissues

Pathology

• defects in ADAMTS10 are a cause of the autosomal recessive form of Weill-Marchesani syndrome

More general terms

• ADAMTS protease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81794
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81794
• OMIM: https://mirror.omim.org/entry/277600
• OMIM: https://mirror.omim.org/entry/608990
• UniProt: http://www.uniprot.org/uniprot/Q9H324.html