A disintegrin & metalloproteinase with thrombospondin type 1 motif 8; ADAMTS-8; ADAM-TS 8; ADAM-TS8; METH-2; METH-8 (ADAMTS8, METH2)

Function

• has anti-angiogenic properties
• precursor is cleaved by a furin endopeptidase

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
• contains 1 disintegrin domain
• contains 1 peptidase M12B domain
• contains 2 TSP type-1 domains

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

• highly expressed in adult & fetal lung,
• lower expression in brain, placenta, heart, stomach & fetal brain & kidney

More general terms

• ADAMTS protease
• glycoprotein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/605175
• UniProt: http://www.uniprot.org/uniprot/Q9UP79.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11095