A disintegrin & metalloproteinase with thrombospondin type 1 motif 6; ADAMTS-6; ADAM-TS 6; ADAM-TS6; (ADAMTS6)

Function

• interaction with the extracellular matrix
• precursor is cleaved by a furin endopeptidase

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
• contains 1 disintegrin domain
• contains 1 peptidase M12B domain
• contains 2 TSP type-1 domains

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

• expressed at low levels in placenta
• barely detectable in a number of other tissues

More general terms

• ADAMTS protease
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/605008
• UniProt: http://www.uniprot.org/uniprot/Q9UKP5.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11174