A disintegrin & metalloproteinase with thrombospondin type 1 motif 3; ADAMTS-3; ADAM-TS 3; ADAM-TS3; procollagen II amino propeptide-processing enzyme; procollagen II N-proteinase; PC II-NP (ADAMTS3, KIAA0366)

Function

• cleaves the propeptides of collagen type 2 prior to fibril assembly.
• does not act on collagen type 1 or collagen type 3
• precursor is cleaved by a furin endopeptidase

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
• contains 1 disintegrin domain
• contains 1 peptidase M12B domain
• contains 1 PLAC domain
• contains 4 TSP type-1 domains

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

found in cartilage & skin

Notes

has been referred to as ADAMTS4

More general terms

• ADAMTS protease
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/O15072.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9508
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9508
• OMIM: https://mirror.omim.org/entry/605011