apoptosis-related protein 3; APR-3; p18 (APR3, ATRAID, C2orf28, HSPC013, UNQ214/PRO240)

Function

• may play a critical role in inducing cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway

Structure

contains 1 EGF-like domain

Compartment

• cell membrane; single-pass membrane protein

Alternative splicing

named isoforms=3

Alternative promoter usage

• at least 2 isoforms produced by alternative promoter usage

Expression

• weakly expressed in hematopoietic cell lines
• up-regulated by all-trans-retinoic acid (ATRA) in several tumor cell lines

More general terms

• apoptosis related protein
• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51374
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51374
• UniProt: http://www.uniprot.org/uniprot/Q6UW56.html