collagen 19 alpha-1; ; collagen alpha-1(Y) (COL19A1)

Introduction

A FACIT collagen

Function

• may act as a cross-bridge between fibrils & other extracellular matrix molecules
• role in skeletal myogenesis in the developing esophagus
• may play a role in organization of the pericellular matrix or the sphinteric smooth muscle
• Pro at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains oligomer; disulfide-linked

Structure

• numerous interruptions in the triple helix may make COL19A1 either elastic or flexible
• belongs to the fibril-associated collagens with interrupted helices (FACIT) family
• contains 1 TSP N-terminal (TSPN) domain

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

• localized to vascular, neuronal, mesenchymal, & some epithelial basement membrane zones in umbilical cord

More general terms

• collagen subunit

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1310
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1310
• OMIM: https://mirror.omim.org/entry/120165
• UniProt: http://www.uniprot.org/uniprot/Q14993.html