collagen 10 alpha-1 (COL10A1)

Function

• type 10 collagen is a product of hypertrophic chondrocytes
• Pro at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains

Structure

• homotrimer
• contains 1 C1q domain

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

-localized to presumptive mineralization zones of hyaline cartilage

Pathology

• defects in COL10A1 are the cause of Schmid type metaphyseal chondrodysplasia

More general terms

• collagen subunit
• Ca+2 binding protein

Component of

• collagen type-10

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1300
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1300
• OMIM: https://mirror.omim.org/entry/120110
• OMIM: https://mirror.omim.org/entry/156500
• UniProt: http://www.uniprot.org/uniprot/Q03692.html