myosin heavy chain 8; myosin-8; myosin heavy chain, skeletal muscle, perinatal; MyHC-perinatal (MYH8)
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Function
Structure
- muscle myosin is a hexameric protein that consists of
- 2 myosin heavy chain subunits
- 2 myosin essential light chain subunits
- 2 myosin regulatory light chain subunits
- each myosin heavy chain can be split into 1 light meromyosin & 1 heavy meromyosin; it can later be split further into 2 globular subfragments (S1) & 1 rod-shaped subfragment (S2)
- rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils
- contains 1 IQ domain
- contains 1 myosin head-like domain
Compartment
- cytoplasm, myofibril
- thick filaments of the myofibrils
Expression
found in perinatal tissue
Pathology
- defects in MYH8 are a cause
More general terms
Additional terms
References
Database
- UniProt: http://www.uniprot.org/uniprot/P13535.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4626
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4626
- OMIM: https://mirror.omim.org/entry/158300
- OMIM: https://mirror.omim.org/entry/160741
- OMIM: https://mirror.omim.org/entry/608837