myosin heavy chain 1; myosin-1; myosin heavy chain 2x; MyHC-2x; myosin heavy chain, skeletal muscle, adult 1; myosin heavy chain IIx/d; MyHC-IIx/d (MYH1)
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Function
Structure
- muscle myosin is a hexameric protein that consists of
- 2 myosin heavy chain subunits
- 2 myosin essential light chain subunits
- 2 myosin regulatory light chain subunits
- each myosin heavy chain can be split into 1 light meromyosin & 1 heavy meromyosin; it can later be split further into 2 globular subfragments (S1) & 1 rod-shaped subfragment (S2)
- the rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils
- contains 1 IQ domain
- contains 1 myosin head-like domain
Compartment
- cytoplasm, myofibril
- thick filaments of the myofibrils
Expression
found in adult skeletal muscle
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P12882.html
- ↑ Pawson T. Protein modules and signalling networks. Nature. 1995 Feb 16;373(6515):573-80. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822