phosphatase-2A regulatory subunit B' (PP2A, subunit B', PR53 isoform, phosphotyrosyl phosphatase activator, PTPAD)

Function

• reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer in presence of ATP & Mg+2 (in vitro)
• associates with PP2A heterodimeric core enzyme, composed of a 36 kD catalytic subunit (subunit C) & a 65 kD constant regulatory subunit (PR65 or subunit A)

Structure

belongs to the PTPA-type PPIase family

Alternative splicing

named isoforms=4

Expression

widely expressed

More general terms

• phosphatase-2A B subunit

Additional terms

• phosphatase-2A (ceramide-activated protein phosphatase)

Database

• OMIM: https://mirror.omim.org/entry/600756
• UniProt: http://www.uniprot.org/uniprot/Q15257.html