inter alpha antitrypsin heavy chain-2 (ITI heavy chain H2, inter-alpha-inhibitor heavy chain 2, inter-alpha-trypsin inhibitor complex component II, serum-derived hyaluronan-associated protein, SHAP, ITIH2, IGHEP2)

Function

• component of I-alpha-I & I-alpha-IL
• carrier of hyaluronan in serum (putative)
• binding protein between hyaluronan & other matrix proteins, including those on cell surfaces
• may regulate localization, synthesis & degradation of hyaluronan

Structure

• belongs to the ITIH family
• contains 1 VWFA domain
• linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage (putative)
• Mass Spectrometry mass=76508; method=MALDI; Range=55-702

Compartment

secreted

More general terms

• inter alpha antitrypsin heavy chain

Component of

• inter alpha trypsin inhibitor (inter-alpha-inhibitor, I-alpha-I)
• I-alpha-I like inhibitor (I-alpha-LI)

Database

• OMIM: https://mirror.omim.org/entry/146640
• UniProt: http://www.uniprot.org/uniprot/P19823.html