laminin gamma-2 (laminin 5 gamma 2 subunit, kalinin/nicein/epiligrin 100 kD subunit, laminin B2t chain, cell-scattering factor 140 kD subunit, CSF 140 kD subunit, large adhesive scatter factor 140 kD subunit, Lln 140 kD subunit, LAMC2, LAMB2T, LAMNB2)

Function

• laminin gamma
• subunit of laminin-5 (epiligrin/kalinin/nicein)
• binds heparin

Structure

• the alpha-helical domains I & II are thought to interact with other laminin chains to form a coiled coil structure
• domain IV is globular
• contains 8 laminin EGF-like domains
• contains 1 laminin IV type A domain

Compartment

• secreted, extracellular space, extracellular matrix
• basement membrane, major component

Alternative splicing

named isoforms=2

Expression

• large variant expressed only in specific epithelial cells of embryonic & neonatal tissues
• in 17-week old embryo, the small variant is found in cerebral cortex, lung, & distal tubes of kidney, but not in epithelia except for distal tubuli

Pathology

• defects in LAMC2 are a cause of epidermolysis bullosa junctional

Laboratory

• LAMC2 gene mutation

More general terms

• laminin-gamma (laminin B2)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3918
• OMIM: https://mirror.omim.org/entry/150292
• OMIM: https://mirror.omim.org/entry/226700
• UniProt: http://www.uniprot.org/uniprot/Q13753.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3918