laminin alpha-4 (laminin A4, LAMA4)

Function

• laminin-alpha

Structure

• the alpha-helical domains I & II are thought to interact with other laminin chains to form a coiled coil structure
• Domain G is globular
• contains 4 laminin EGF-like domains
• contains 5 laminin G-like domains

Compartment

• secreted, extracellular space, extracellular matrix
• basement membrane, major component

Alternative splicing

named isoforms=2

Expression

• in adult, expressed in heart, lung, ovary small & large intestines, placenta, liver > skeletal muscle, kidney, pancreas, testis, prostate, brain
• high expression in fetal lung & kidney
• expression in fetal & newborn tissues is observed in certain mesenchymal cells in tissues such as smooth muscle & dermis

Notes

gene LAMA4 was formerly called LAMA3

More general terms

• laminin-alpha (laminin A)

Database

• OMIM: https://mirror.omim.org/entry/600133
• UniProt: http://www.uniprot.org/uniprot/Q16363.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3910