eukaryotic initiation factor 2-gamma; eIF2-gamma (EIF2S3)

Function

• eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP & initiator tRNA
• this complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex
• junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 & release of an eIF-2-GDP binary complex
• in order for eIF-2 to recycle & catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B
• eIF-2 is a heterotrimer composed of an alpha, beta & gamma chain

Structure

• belongs to the GTP-binding elongation factor family EIF2G subfamily

More general terms

• eukaryotic initiation factor subunit

Component of

• eukaryotic initiation factor 2

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1968
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1968
• OMIM: https://mirror.omim.org/entry/300161
• UniProt: http://www.uniprot.org/uniprot/P41091.html