NADH dehydrogenase MWFE subunit (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1, complex 1-MWFE, NDUFA1)

Function

• accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex 1)
• not involved in catalysis

Structure

belongs to the complex 1 NDUFA1 subunit family

Compartment

mitochondrial inner membrane; matrix side

Expression

• primarily expressed in heart & skeletal muscle

Pathology

• defects in NDUFA1 are a cause of NADH dehydrogenase deficiency

More general terms

• NADH dehydrogenase subunit

Component of

• NADH dehydrogenase; respiratory chain complex-I; NADH CoQ reductase;NADH-ubiquinone oxidoreductase

Database

• UniProt: http://www.uniprot.org/uniprot/O15239.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4694
• OMIM: https://mirror.omim.org/entry/252010
• OMIM: https://mirror.omim.org/entry/300078