cytochrome c oxidase subunit 2; cytochrome c oxidase polypeptide II (MT-CO2, COII, COXII, MTCO2)

Function

• subunit of cytochrome c oxidase
• cytochrome c oxidase subunits MT-CO1, MT-CO2, & MT-CO3 form the functional core of the enzyme complex
• subunit 2 transfers electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1

Cofactor: copper A

Structure

• belongs to the cytochrome c oxidase subunit 2 family

Compartment

• mitochondrial inner membrane; multi-pass membrane protein

Pathology

• defects in MT-CO2 are a cause of cytochrome c oxidase deficiency

More general terms

• enzyme catalytic subunit
• cytochrome c oxidase subunit

Component of

• cytochrome c oxidase (complex IV)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4513
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4513
• OMIM: https://mirror.omim.org/entry/220110
• OMIM: https://mirror.omim.org/entry/516040
• UniProt: http://www.uniprot.org/uniprot/P00403.html