NACHT, LRR & PYD-containing protein 12; PYRIN-containing APAF1-like protein 7; monarch-1; regulated by nitric oxide (NALP12, NLRP12, PYPAF7, RNO)

Function

• mediates activation of CASP1 via ASC & promotes activation of NF-kappa-B via IKK (putative)
• binds to ASC with its DAPIN domain

Structure

• contains 1 DAPIN domain contains 8 LRR repeats (leucine-rich repeats) contains 1 NACHT domain

Compartment

cytoplasm

Alternative splicing

named isoforms=5

Expression

• expressed only in peripheral blood leukocytes, predominantly in eosinophils & granulocytes > monocytes
• induced by nitric oxide & DMSO in HL60 cells

More general terms

• NACHT, LRR & PYD-containing protein (NALP)

Database

• UniProt: http://www.uniprot.org/uniprot/P59046.html