COMM domain-containing protein 6 (COMMD6)

Function

• inhibits TNF-induced NFKB1 activation
• interact directly with COMMD1
• does not interact with NFKBIB

Structure

• contains 1 COMM domain
• homodimer, can only homodimerize with isoform 1

Compartment

nucleus, cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine & placenta

More general terms

• COMM domain-containing protein (COMMD)

Database

• UniProt: http://www.uniprot.org/uniprot/Q7Z4G1.html