late cornified envelope protein 2D; late envelope protein 12; small proline-rich-like epidermal differentiation complex protein 1A (LCE2D, LEP12, SPRL1A)

Function

• precursors of cornified envelope of stratum corneum

Structure

belongs to the LCE family

Expression

• skin-specific
• expression in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus, tongue
• not expressed in the cervix, rectum, lung, colon, placenta
• induction by Ca+2 & UVB

Genetics

• gene belongs to the LCE cluster present on 1q21

More general terms

• late cornified envelope protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=353141
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:353141
• OMIM: https://mirror.omim.org/entry/612612
• UniProt: http://www.uniprot.org/uniprot/Q5TA82.html