alkylated DNA repair protein alkB homolog 7; alpha-ketoglutarate-dependent dioxygenase ABH7; spermatogenesis cell proliferation-related protein; spermatogenesis-associated protein 11 (ALKBH7, ABH7, SPATA11, UNQ6002/PRO34564)

Function

• dioxygenase
• requires molecular oxygen, alpha-ketoglutarate & iron (putative)
• may promote cell death in cells with massive DNA damage

Cofactor: binds 1 Fe+2 ion per subunit (putative)

Structure

belongs to the alkB family

Compartment

• cytoplasm, nucleus. secreted (putative)
• has a predicted N-terminal signal sequence, indicating it may be secreted
• detected in cytoplasm & nucleus when expressed as fusion protein with an N-terminal tag

Expression

• widely expressed
• expressed in pancreas > spleen, prostate, ovary & placenta

More general terms

• alkylated DNA repair protein alkB homolog (ALKBH)
• dioxygenase
• metalloprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84266
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84266
• OMIM: https://mirror.omim.org/entry/613305
• UniProt: http://www.uniprot.org/uniprot/Q9BT30.html