WW domain-binding protein 4 (WBP-4, formin-binding protein 21, WBP4, FBP21, FNBP21)

Function

• spliceosome-associated protein
• cross-intron bridging of U1 & U2 snRNPs in the mammalian A complex
• associated with U2 snRNPs
• binds splicing factors SNRPB, SNRPC & SF1

Structure

• contains 1 matrin-type zinc finger
• contains 2 WW domains that recognize a proline, glycine, & methionine-rich (PGM) motif present in splicing factors

Compartment

nucleus, nuclear speckle

More general terms

• WW domain-binding protein
• formin binding protein

Database

• OMIM: https://mirror.omim.org/entry/604981
• UniProt: http://www.uniprot.org/uniprot/O75554.html