GSK-3-binding protein FRAT2; frequently rearranged in advanced T-cell lymphomas 2; FRAT-2 (FRAT2)

Function

• positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3
• binds GSK-3 & prevents GSK-3-dependent phosphorylation

Structure

• belongs to the GSK-3-binding protein family

More general terms

• GSK-3 binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23401
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23401
• OMIM: https://mirror.omim.org/entry/605006
• UniProt: http://www.uniprot.org/uniprot/O75474.html