regulator of G-protein signaling 18 (RGS18)

Function

• inhibits signal transduction by increasing GTPase activity of G-alpha subunits increasing the amount of inactive GDP-bound form
• binds to Gi-alpha-1, Gi-alpha-2, Gi-alpha-3 & Gq-alpha

Structure

contains 1 RGS domain

Compartment

cytoplasm (putative)

Expression

• expressed in peripheral leukocytes, bone marrow, platelets, spleen & fetal liver

More general terms

• regulator of G-protein signaling

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64407
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64407
• OMIM: https://mirror.omim.org/entry/607192
• UniProt: http://www.uniprot.org/uniprot/Q9NS28.html