regulator of G-protein signaling 8 (RGS8)

Function

• inhibits signal transduction by increasing GTPase activity of G-alpha subunits thus increasing the amount of inactive GDP-bound form
• preferentially binds to Go-alpha & Gi-alpha-3 (putative)

Structure

contains 1 RGS domain

Alternative splicing

named isoforms=2

More general terms

• regulator of G-protein signaling

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=85397
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:85397
• OMIM: https://mirror.omim.org/entry/607189
• UniProt: http://www.uniprot.org/uniprot/P57771.html