regulator of G-protein signaling 5 (RGS5)

Function

• inhibits signal transduction by increasing GTPase activity of G-alpha subunits thus increasing the amount of inactive GDP-bound form
• binds to Gi-alpha & Go-alpha
• does not bind Gs-alpha (putative)

Structure

contains 1 RGS domain

More general terms

• regulator of G-protein signaling

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8490
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8490
• OMIM: https://mirror.omim.org/entry/603276
• UniProt: http://www.uniprot.org/uniprot/O15539.html