BAG family molecular chaperone regulator 5; BAG-5; Bcl-2-associated athanogene 5 (BAG5, KIAA0873)

Function

• inhibits chaperone activity of HSP70/HSC70 by promoting substrate release
• inhibits both auto-ubiquitination of PARK2 & ubiquitination of target proteins by PARK2
• binds to the ATPase domain of HSP70/HSC chaperones
• binds PARK2 (putative)

Structure

contains 4 BAG domains

More general terms

• bcl-2 binding athanogene (bag) protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9529
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9529
• OMIM: https://mirror.omim.org/entry/603885
• UniProt: http://www.uniprot.org/uniprot/Q9UL15.html