Vacuolar protein sorting-associated protein 37A (hVps37A, hepatocellular carcinoma-related protein 1, VPS37A, HCRP1)

Function

• component of the ESCRT-1 complex
• required for sorting of endocytic ubiquitinated cargos into multivesicular bodies
• may be involved in cell growth & differentiation
• interacts with TSG101

Structure

• belongs to the VPS37 family
• contains 1 VPS37 C-terminal domain

Compartment

• cytoplasm
• late endosome membrane, peripheral membrane
• nucleus

Alternative splicing

named isoforms=3

Expression

• widely expressed, more abundant in liver

Pathology

• strongly decreased or undetected in hepatomas

More general terms

• vacuolar protein sorting-associated protein (VPS)

Component of

• ESCRT-1 complex; endosomal sorting complex required for transport 1

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NEZ2.html