long-chain-fatty-acid--CoA ligase ACSBG2; acyl-CoA synthetase bubblegum family member 2; bubblegum-related protein; PRTD-NY3 (ACSBG2, BGR, UNQ2443/PRO5005)

Function

• mediates activation of long-chain fatty acids for both synthesis of cellular lipids, & degradation via beta-oxidation
• able to activate long-chain fatty acids
• also able to activate very long-chain fatty acids; however, relevance in vivo unclear
• has increased ability to activate oleic & linoleic acid
• may play a role in spermatogenesis

ATP + a long-chain carboxylic acid + CoA <--> AMP + diphosphate + an acyl-CoA

Structure

• belongs to the ATP-dependent AMP-binding enzyme family, bubblegum subfamily

Compartment

cytoplasm, peripheral membrane

Alternative splicing

named isoforms=4

Expression

• testis-specific
• weakly or not expressed in fetal testis
• highly expressed in adult testis & moderately in elderly testis

More general terms

• fatty-acid CoA ligase
• testis-specific protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81616
• UniProt: http://www.uniprot.org/uniprot/Q5FVE4.html