sperm-associated antigen 8 (sperm membrane protein 1, SMP-1, HSD-1, sperm membrane protein BS-84, SPAG8)

Function

• role in fertility & microtubule formation via interaction with RANBP9

Compartment

-acrosome

• acrosomal region of head of mature sperm cells

Alternative splicing

named isoforms=2

Expression

• expressed in testis (germ cells)
• not expressed in liver, kidney, prostate & small intestine

Pathology

• antibodies against SPAG8 may be associated with female infertility

More general terms

• testis-specific protein

Database

• OMIM: https://mirror.omim.org/entry/605731
• UniProt: http://www.uniprot.org/uniprot/Q99932.html