testis-expressed protein 14 (testis-expressed sequence 14, protein kinase-like protein SgK307, Sugen kinase 307, TEX14)

Function

• required for spermatogenesis & male fertility
• role in normal structure of the intercellular bridge that connects spermatocytes & spermatogonia
• no protein kinase activity (in vitro) Structure:
  • contains 3 ANK repeats contains 1 protein kinase domain.
    • Ser-376 is present instead of the conserved Asp which is expected to be an active site residue

Compartment

• cytoplasm
• detected in the intercellular bridges that connect male germ cell daughter cells after cell division

Alternative splicing

named isoforms=3

More general terms

• testis-specific protein

Database

• OMIM: https://mirror.omim.org/entry/605792
• UniProt: http://www.uniprot.org/uniprot/Q8IWB6.html