PMS1 protein homolog 1; postmeiotic segregation increased-1; DNA mismatch repair protein PMS1 (PMS1, PMSL1)

Function

• probably involved in the repair of mismatches in DNA

Structure

• belongs to the DNA mismatch repair mutL/hexB family
• contains 1 HMG box DNA-binding domain

Compartment

nucleus (putative)

Pathology

• defects in PMS1 are the cause of hereditary non-polyposis colorectal cancer type 3

More general terms

• mutL/PMS1 family protein
• nuclear protein

Additional terms

• DNA mismatch repair; post-replication repair; DNA loop repair

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5378
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5378
• OMIM: https://mirror.omim.org/entry/600258
• UniProt: http://www.uniprot.org/uniprot/P54277.html