DNA mismatch repair protein Mlh3; mutL protein homolog 3 (MLH3)

Function

• DNA mismatch repair protein
• heterodimer of MLH1 & MLH3

Structure

• belongs to the DNA mismatch repair mutL/hexB family

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• highly expressed in gastrointestinal epithelium

Pathology

• defects in MLH3 are the cause of hereditary non-polyposis colorectal cancer type 7
• defects in MLH3 are a cause of colorectal cancer

More general terms

• mutL/PMS1 family protein
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27030
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27030
• OMIM: https://mirror.omim.org/entry/114500
• OMIM: https://mirror.omim.org/entry/604395
• UniProt: http://www.uniprot.org/uniprot/Q9UHC1.html