Wiskott-aldrich syndrome protein family member 2; WASP family protein member 2; protein WAVE-2; verprolin homology domain-containing protein 2 (WASF2, WAVE2)

Function

• downstream effector involved in signal tranduction from tyrosine kinase receptors & small GTPases to the actin cytoskeleton
• binds actin & the Arp2/3 complex
• interacts with BAIAP2
• component of the WAVE2 complex
• directly interacts with C3orf10/HSPC300

Structure

• binds the Arp2/3 complex through the C-terminal region & actin through verprolin homology (VPH) domain
• belongs to the SCAR/WAVE family
• contains 1 WH2 domain

Compartment

• cytoplasm, cytoskeleton (putative)
• cell projection, lamellipodium (putative)
• at the interface between the lamellipodial actin meshwork & the membrane (putative)

Expression

• expressed in all tissues
• strongest expression in placenta, lung, & peripheral blood leukocytes

More general terms

• Wiskott Aldrich syndrome protein family (WASF)
• phosphoprotein

Component of

• WAVE2 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10163
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10163
• OMIM: https://mirror.omim.org/entry/605875
• UniProt: http://www.uniprot.org/uniprot/Q9Y6W5.html