protein BCL8 (BCL8, BCL8A, NBEAP1)

Expression

expressed in prostate & testis

Pathology

• chromosomal translocation t(14;15)(q32;q11-q13) involving BCL8 with IgH has been observed in diffuse large cell lymphoma (DLCL).
• the BCL8/IgH translocation leaves the coding region of BCL8 intact, but may have pathogenic effects due to alterations in the expression level of BCL8

Notes

could be the product of a pseudogene

More general terms

• bcl protein (B-cell leukemia/lymphoma protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=606
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:606
• OMIM: https://mirror.omim.org/entry/601889
• UniProt: http://www.uniprot.org/uniprot/P0C6P0.html