roundabout homolog 4 (Magic roundabout, ROBO4)

Function

• receptor for Slit proteins, at least for SLIT2
• role in angiogenesis & vascular patterning
• mediates inhibition of primary endothelial cell migration by Slit proteins
• interacts with SLIT2 & ENAH

Structure

• belongs to the immunoglobulin superfamily, ROBO family
• contains 2 fibronectin F3 modules contains 2 Ig-like C2-type domains (immunoglobulin-like)

Alternative splicing

named isoforms=4

Expression

• specifically expressed in endothelial cells
• expressed at sites of angiogenesis in different tumor types

More general terms

• immunoglobulin superfamily protein

Database

• OMIM: https://mirror.omim.org/entry/607528
• UniProt: http://www.uniprot.org/uniprot/Q8WZ75.html