armadillo repeat protein deleted in velo-cardio-facial syndrome (ARVCF)

Function

• role in protein-protein interactions at adherens junctions
• interacts (via C-terminus) with FRMPD2 (via PDZ domain 2)

Structure

• belongs to the beta-catenin family
• contains 10 ARM repeats

Alternative splicing

named isoforms=2; long, short

Expression

• found in all the examined tissues including heart, brain, liver & kidney
• found at low level in lung

More general terms

• beta catenin family protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=421
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:421
• OMIM: https://mirror.omim.org/entry/602269
• UniProt: http://www.uniprot.org/uniprot/O00192.html