dual specificity testis-specific protein kinase 2; testicular protein kinase 2 (TESK2)

Function

• dual specificity protein kinase activity catalyzing autophosphorylation & phosphorylation of exogenous substrates on both Ser/Thr & Tyr
• phosphorylates cofilin at Ser-3
• may play an role in spermatogenesis
• activated by autophosphorylation on Ser-219

ATP + a protein = ADP + a phosphoprotein

Cofactor: Mg+2, Mn+2 (putative)

Structure

• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family
• contains 1 protein kinase domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• predominantly expressed in testis & prostate
• found predominantly in non-germinal Sertoli cells

More general terms

• testicular protein kinase (testis-specific protein kinase)
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10420
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10420
• OMIM: https://mirror.omim.org/entry/604746
• UniProt: http://www.uniprot.org/uniprot/Q96S53.html