mitogen activated protein kinase kinse kinase kinase 3 (MAP4K3, MAPKKKK3, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, MEKKK 3, germinal center kinase-like kinase, GLK)

Function

• may play a role in the response to environmental stress
• appears to act upstream of the JUN N-terminal pathway
• interaction with SH3GL2 appears to regulate MAP4K3-mediated JNK activation
• activates JNK but not MAPK1, MAPK3 or MAPK14 through activation of MAP3K1 & MAP2K4.
• activity stimulated by TNF

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
• contains 1 CNH domain contains 1 protein kinase domain

Alternative splicing

named isoforms=3

Expression

• ubiquitously expressed in all tissues examined
• expression in heart, brain, placenta, skeletal muscle, kidney & pancreas > lung & liver

More general terms

• mitogen activated protein kinase kinse kinase kinase

Database

• OMIM: https://mirror.omim.org/entry/604921
• UniProt: http://www.uniprot.org/uniprot/Q8IVH8.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8491