protein kinase A [PKA] catalytic subunit alpha (PRKACA)

Function

• cAMP kinase, catalytic subunit of protein kinase A
• Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB & CA respectively

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 protein kinase domain

Compartment

• cytoplasm (putative), nucleus
• translocates into the nucleus (monomeric catalytic subunit)
• the inactive holoenzyme is found in the cytoplasm (putative)

Alternative splicing

named isoforms=2

Expression

isoform 2 is sperm specific

More general terms

• cAMP kinase

Additional terms

• protein kinase A

Database

• UniProt: http://www.uniprot.org/uniprot/P17612.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5566
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7304
• OMIM: https://mirror.omim.org/entry/601639