dual specificity protein phosphatase 10 (MAP kinase phosphatase 5, DUSP10, MKP5)

Function

• role in the inactivation of MAP kinases
• specificity for MAPK11, MAPK12, MAPK13, MAPK14 (p38-mapks)

protein tyrosine phosphate + H2O
                  <-->
protein tyrosine + phosphate

a phosphoprotein + H2O <--> a protein + phosphate

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class dual specificity subfamily
• contains 1 rhodanese domain
• contains 1 tyrosine-protein phosphatase domain

Compartment

cytoplasm, nucleus

More general terms

• dual specificity phosphatase
• mitogen activated protein kinase phosphatase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1122
• OMIM: https://mirror.omim.org/entry/608867
• UniProt: http://www.uniprot.org/uniprot/Q9Y6W6.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11221