dual specificity protein phosphatase 7 (MAP kinase phosphatase X, dual specificity protein phosphatase PYST2, DUSP7, PYST2)

Function

• regulates activity of the MAP kinase family in response to changes in the cellular environment
• PYST2-S may act as a negative regulator of PYST2-L (mechanism uncertain)

protein tyrosine phosphate + H2O
               <-->
protein tyrosine + phosphate

phosphoprotein + H2O <--> a protein + phosphate

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class dual specificity subfamily
• contains 1 rhodanese domain
• contains 1 tyrosine-protein phosphatase domain

Compartment

cytoplasm Alternative promoter:

• named isoforms=2 (PYST2-L, PYST2A-S)

Pathology

• expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells

Notes

• an out-of-frame translation product, PYST2SB, has been experimentally demonstrated to be formed from the alternative promoter

expression of the in-frame product has not yet been shown

More general terms

• dual specificity phosphatase
• mitogen activated protein kinase phosphatase

Database

• OMIM: https://mirror.omim.org/entry/602749
• UniProt: http://www.uniprot.org/uniprot/Q16829.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1849